Synthesis and Anti-platelet, Anti-inflammatory and Anti-allergic Activities of Methoxyisoflavanquinone and Related Compounds

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概要

• 論文の詳細を見る

• In a continuation of our search for novel anti-platelet agents, isoflavone quinone and isoflavanquinone were selected as lead compounds and the synthesis of their methoxy derivatives was carried out. Among them, the 4'-and 7-methoxy derivatives were successfully prepared, whereas the attempt to obtain 3'-methoxy derivatives resulted in their isomers, 3'-methoxyflavone quinone and 3'-methoxyflavanquinone, instead.After screening for their anti-platelet, anti-inflammatory and anti-allergic activities, a preliminary structure-activity relationship was established.Compounds 6c, 7a-c, 8c and 9a-c were found to exhibit significant activities. In particular, compound 7c demonstrated very potent anti-platelet, anti-inflammatory and anti-allergic activities and was then recommended for further pharmacological investigation.

• 公益社団法人日本薬学会の論文
• 2000-07-01

著者

• HUANG Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• KUO Sheng-Chu

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• Tzeng C‐c

  Kaohsiung Medical Univ. Kaohsiung City Twn

• Teng C‐m

  National Taiwan Univ. Taipei Twn

• Teng Che-ming

  Pharmacological Institute College Of Medicine National Taiwan University

• Huang L‐j

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Huang Li-jiau

  Graduate Institute Of Pharmaceutical Chemistry College Of Pharmacy China Medical University

• Kuo S‐c

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Kuo Sheng-chu

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Wang J‐p

  Department Of Education And Research Taichung Veterans General Hospital

• CHANG Chiung-Yun

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• WANG Jih-Pyang

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• CHEN Sheng-Chih

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• Chen S‐c

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Chang Chiung-yun

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Huang Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry China Medical College

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• Synthesis and Antiplatelet Evaluation of α-Methylene-γ-butyrolactone Bearing 2-Methylquinoline and 8-Hydroxyquinoline Moieties
• Synthesis and Anti-platelet, Anti-inflammatory and Anti-allergic Activities of Methoxyisoflavanquinone and Related Compounds
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