Synthesis and Antiplatelet Evaluation of α-Methylene-γ-butyrolactone Bearing 2-Methylquinoline and 8-Hydroxyquinoline Moieties

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概要

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• In a serach for inhibitors of platelet aggregation, some α-methylene-γ-butyrolactones bearing 2-methylquinoline and 8-hydroxyquinoline moieties were synthesized and evaluated for antiplatelet activities against thrombin (Thr)-, arachidonic acid (AA)-, collagen (Col)-, and platelet-activating factor (PAF)- induced aggregation in washed rabbit platelets. With the exception of 2-[[2,3,4,5-tetrahydro-4-methylene-5-oxo-2-(4-phenylphenyl)-2-furanyl]methoxy]-8-hydroxyquinoline (8f), these α-methylene-γ-butyrolactones completely inhibited the platelet aggregation induced by AA and Col. The 2-methylquinoline derivatives were also active against Thr- and PAF-induced aggregation, while their 8-hydroxyquinoline counterparts were relatively inactive.

• 公益社団法人日本薬学会の論文
• 1997-11-15

著者

• Tzeng C‐c

  Kaohsiung Medical Univ. Kaohsiung City Twn

• Teng C‐m

  National Taiwan Univ. Taipei Twn

• Teng Che-ming

  Pharmacological Institute College Of Medicine National Taiwan University

• TZENG Cherng-Chyi

  School of Chemistry, Kaohsiung Medical College

• Chen Y‐l

  Kaohsiung Medical Coll. Kaohsiung Twn

• Chang Ya-ling

  School Of Chemistry Kaohsiung Medical College:department Of Chemistry National Sun Yat-sen Universit

• Zhao Yue-ling

  Department Of Pharmacy Tajen Junior College Of Pharmacy:school Of Chemistry Kaohsiung Medical Colleg

• CHANG Ya-Ling

  Pharmacological Institute, College of Medicine, National Taiwan University

• LIOU Shorong-Shii

  Department of Pharmacy, Tajen Junior College of Pharmacy

• Tzeng Cherng-chyi

  School Of Chemistry Kaohsiung Medical University

• Liou Shorong-shii

  Department Of Pharmacy Tajen Junior College Of Pharmacy

関連論文

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• Synthesis of 2-Alkoxy 1,4-Naphthoquinone Derivatives as Antiplatelet, Antiinflammatory, and Antiallergic Agents
• Synthesis and Evaluation of Coumarin α-Methylene-γ-butyrolactones : A New Class of Platelet Aggregation Inhibitors
• Antiplatelet Effect and Selective Binding to Cyclooxygenase by Molecular Docking Analysis of 3-Alkylaminopropoxy-9,10-anthraquinone Derivatives(Medicinal Chemistry)
• α-Methylene-γ-butyrolactones : Synthesis and Vasorelaxing Activity Assay of Coumarin, Naphthalene, and Quinoline Derivatives
• Synthesis and Antiplatelet Evaluation of α-Methylene-γ-butyrolactone Bearing 2-Methylquinoline and 8-Hydroxyquinoline Moieties
• Synthesis and Anti-platelet, Anti-inflammatory and Anti-allergic Activities of Methoxyisoflavanquinone and Related Compounds
• Effect of PP1D-1, a Synthetic Antiplatelet Compound, on Rabbit Platelets
• The Inhibitory Mechanism of YC-1, a Benzyl Indazole, on Smooth Muscle Cell Proliferation : an In Vitro and In Vivo Study
• Crystal Structure of 3-Amino-1,2,4-triazin-5(2H)-one
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