Synthesis of 2-Alkoxy 1,4-Naphthoquinone Derivatives as Antiplatelet, Antiinflammatory, and Antiallergic Agents

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概要

• 論文の詳細を見る

• In our continuing search for novel antiplatelet, antiallergic, and antiinflammatory agents, 2-alkoxy derivatives of 1,4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, antiallergic, and antiinflammatory activities. Among them, 2-propoxy-1,4-naphthoquinone and 2-butoxy-1,4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion formation. These two compounds are worthy of further exploration.

• 社団法人日本薬学会の論文
• 2002-05-01

著者

• HUANG Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• KUO Sheng-Chu

  Graduate Institute of Pharmaceutical Chemistry, College of Pharmacy, China Medical University

• Tzeng C‐c

  Kaohsiung Medical Univ. Kaohsiung City Twn

• Teng C‐m

  National Taiwan Univ. Taipei Twn

• Teng Che-ming

  Pharmacological Institute College Of Medicine National Taiwan University

• Huang L‐j

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Huang Li-jiau

  Graduate Institute Of Pharmaceutical Chemistry College Of Pharmacy China Medical University

• Kuo S‐c

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Kuo Sheng-chu

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• LIEN Jin-Cherng

  Graduate Institute of Pharmaceutical Chemistry, China Medical College

• WANG Jih-Pyang

  Department of Medical Research, Taichung Veterans General Hospital

• Lien Jin-cherng

  Graduate Institute Of Pharmaceutical Chemistry China Medical College

• Wang J‐p

  Department Of Education And Research Taichung Veterans General Hospital

• Wang Jih-pyang

  Department Of Education And Research Taichung Veterans General Hospital

• Huang Li-Jiau

  Graduate Institute of Pharmaceutical Chemistry China Medical College

関連論文

• The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells
• Synthesis and Antiplatelet, Antiinflammatory and Antiallergic Activities of 2,3-Disubstituted 1,4-Naphthoquinones
• Synthesis of 2-Alkoxy 1,4-Naphthoquinone Derivatives as Antiplatelet, Antiinflammatory, and Antiallergic Agents
• Protective Effect of Broussonetia papyrifera against Hydrogen Peroxide-Induced Oxidative Stress in SH-SY5Y Cells
• Synthesis and Evaluation of Coumarin α-Methylene-γ-butyrolactones : A New Class of Platelet Aggregation Inhibitors
• Antiplatelet Effect and Selective Binding to Cyclooxygenase by Molecular Docking Analysis of 3-Alkylaminopropoxy-9,10-anthraquinone Derivatives(Medicinal Chemistry)
• α-Methylene-γ-butyrolactones : Synthesis and Vasorelaxing Activity Assay of Coumarin, Naphthalene, and Quinoline Derivatives
• Synthesis and Antiplatelet Evaluation of α-Methylene-γ-butyrolactone Bearing 2-Methylquinoline and 8-Hydroxyquinoline Moieties
• Synthesis and Anti-platelet, Anti-inflammatory and Anti-allergic Activities of Methoxyisoflavanquinone and Related Compounds
• Effect of PP1D-1, a Synthetic Antiplatelet Compound, on Rabbit Platelets
• The Inhibitory Mechanism of YC-1, a Benzyl Indazole, on Smooth Muscle Cell Proliferation : an In Vitro and In Vivo Study
• Protective Effect of Broussonetia papyrifera against Hydrogen Peroxide-Induced Oxidative Stress in SH-SY5Y Cells
• Ca2+-Channel Blockade in Rat Thoracic Aorta by Protopine Isolated from Corydalis Tubers.

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