Dyscusins A—C, Three New Steroids from the Leaves of Dysoxylum cumingianum
スポンサーリンク
概要
- 論文の詳細を見る
Three new steroids dyscusins A—C (1—3), including a stigmastane-type sterol and two pregnanes, together with two known steroids were isolated from the leaves of Dysoxylum cumingianum (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic analyses. In a cytotoxicity assay, compound 1 showed ten-fold enhanced cytotoxicity against multi-drug resistant cancer cells (KB-C2) in the presence of 2.5 μM colchicine as compared with the absence of colchicine. This notable finding indicated that 1 possessed a multi-drug resistant reversal effect.
- 公益社団法人 日本薬学会の論文
著者
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Lee Kuo-hsiung
Natural Products Laboratory Division Of Medicinal Chemistry And Natural Products School Of Pharmacy
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柏田 良樹
徳島大院薬
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Takaishi Yoshihisa
Graduate School Of Pharmaceutical Sciences University Of Tokushima
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柏田 良樹
Faculty Of Pharmaceutical Sciences Kyushu Unversity
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Kashiwada Y
Niigata Univ. Pharmacy And Applied Life Sci. Niigata Jpn
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Kashiwada Yoshiki
Graduate School Of Pharmaceutical Sciences University Of Tokushima
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Morris-natschke Susan
Natural Products Laboratory School Of Pharmacy University Of North Carolina
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Kurimoto Shin-ichiro
Graduate School of Pharmaceutical Sciences, University of Tokushima
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Kurimoto Shin-ichiro
Graduate School Of Pharmaceutical Sciences University Of Tokushima
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Takaishi Yoshihisa
Graduate School Of Pharmaceutical Sciences Univ. Of Tokushima
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Lee Kuo-Hsiung
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina
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Morris-Natschke Susan
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina
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