Structures and Antiproliferative Activity of Saponins from Sechium pittieri and S. talamancense
スポンサーリンク
概要
- 論文の詳細を見る
Six bisdesmosidic bayogenin saponins, named tacacosides A_1,A_2,B_1,B_2,B_3 and C, were isolated from the fruit and aerial parts of Sechium pittieri (COGN.) C. KEFFREY and S. talamancense (WUNDERLIN) C. JEFFREY, Costa Rican cucurbitaceae plants. Their structures were elucidated based on spectral and chemical evidence as follows. Tacacoside A_1 : 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]bayogenin 28-O-{α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-β-D-apiofuranaosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} ester, tacacoside A_2 : 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]bayogenin 28-O-{α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} ester, tacacoside B_1 : 3-O-[β-D-glucopyranosyl]bayogenin 28-O-{α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-[β-D-apiofuranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} ester, tacacoside B_2 : 3-O-[β-D-glucopyranosyl]bayogenin 28-O-{α-L-rhamnopyranosyl-(1→3)-β-X-xylopyranosyl-(1→4)-[β-D-xylopyranosyl-(1→3)]-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl} ester, tacacoside B_3 : 3-O-[β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl]bayogenin 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl] ester, and tacacoside C : 3-O-[β-D-glucopyranosyl]bayogenin 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl] ester. These saponins showed moderate antiproliferative activity (ED_<50> : 10-74μg/ml) against MK-1,HeLa and B16F10 cells.
- 社団法人日本薬学会の論文
- 1997-02-15
著者
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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Katano Mitsuo
Department Of Surgery Saga Medical School
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Katano Mitsuo
Department Of Cancer Therapy And Research Graduate School Of Medical Sciences Kyushu University
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Mori Masao
Faculty Of Hospital Pharmacy Saga Medical School
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OKABE Hikaru
Faculty of Pharmaceutical Sciences, Fukuoka University
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NAGAO Tsuneatsu
Faculty of Pharmaceutical Sciences, Fukuoka University
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Okabe Hikaru
Faculty Of Pharmaceutical Sciences Fukuoka University
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岡部 光
福岡大学
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Okabe Hikaru
福岡大学 薬学部
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岡部 光
福岡大学薬学部
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Katano M
Department Of Surgery Saga Medical School
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Castro V
Centro De Investigaciones En Productos Naturales Universidad De Costa Rica
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Mori M
Department Of Pharmacy Saga University Hospital
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Mori M
Faculty Of Hospital Pharmacy Saga Medical School
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Mori M
The Institute Of Physical And Chemical Research (riken)
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MATSUNAGA Hisashi
Faculty of Hospital Pharmacy, Saga Medical School
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MORI Masato
Faculty of Hospital Pharmacy, Saga Medical School
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CASTRO Victor
Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
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EAMIREZ Erick
Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
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MORA Gerardo
Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
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IWASE Yukiko
Faculty of Pharmaceutical Sciences, Fukuoka University
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Mora G
Centro De Investigaciones En Productos Naturales Universidad De Costa Rica
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森 昌斗
Hospital Pharmacy Saga Medical School
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Mora Gerardo
Centro De Investigacion En Productos Naturales Universidad De Costa Rica
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Iwase Y
Faculty Of Pharmaceutical Sciences Fukuoka University
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Iwase Yukiko
Fac. Of Pharmaceutical Sciences Fukuoka Univ.
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Iwase Yukiko
Faculty Of Pharmaceutical Sciences Fukuoka University
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Castro Victor
Centro De Investigacion En Productos Naturales Universidad De Costa Rica
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Eamirez Erick
Centro De Investigaciones En Productos Naturales Universidad De Costa Rica
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Nagao Tsuneatsu
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga H
Takeda Chemical Ind. Ltd. Osaka Jpn
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Matsunaga H
Dep. Of Pharmacy Okayama Univ. Hospital
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Ramirez Eric
Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica
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