Inhibitors of Angiotensin Converting Enzyme in Crude Drugs. I
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概要
- 論文の詳細を見る
Hot 50% MeOH extracts of crude drugs considered to have a hypotensive effect were tested for inhibitory effects on hog kidney angiotensin converting enzyme. Of 65 samples tested, 14 showed reproducible inhibition in the preliminary screening. The extracts of 8 potent samples were fractionated by MCI gel and Sephadex LH-20 gel chromatographies to concentrate the inhibitors. The most potent fractions of Arecae Semen, Ephedrae Herba, Epimedii Herba, Polygoni avicularis Herba, Potentillae Herba and Rhei Rhizoma showed more than 90% inhibition at the concentration of 20μg/ml. Those of Moutan Cortex and Cinnamomi Cortex showed 86 and 78% inhibitions, respectively, at the same concentration. All of these fractions consisted of tannin-type compounds.
- 社団法人日本薬学会の論文
- 1984-09-25
著者
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岡部 光
Faculty Of Pharmaceutical Sciences Fukuoka University
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井ノ口 仁一
Faculty Of Pharmaceutical Sciences Fukuoka University
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山内 辰郎
Faculty of Pharmaceutical Sciences, Fukuoka University
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永松 淳雄
Faculty of Pharmaceutical Sciences, Fukuoka University
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永松 淳雄
福岡大学薬学部
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永松 淳雄
Faculty Of Pharmaceutical Sciences Fukuoka University
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山内 辰郎
Faculty Of Pharmaceutical Sciences Fukuoka University
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