Octa (Per)-, Hepta- and Mono-Acetates of Dioscin

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概要

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• Acetylation of dioscin (I) with acetic anhydride-pyridine (1 : 1) at 10°for 24 hr gave, as the major product, a heptaacetate (III), mp 130-135°, [α]_D-82.0° (MeOH), [α]_D-85.3° (CHCl_3), in which one hydroxyl group, probably at C-3 of the glucose unit, is free. Dioscin octa (per) acetate (V), mp 145-147°, [α]_D -67.5° (MeOH), [α]_D -61.9° (CHCl_3), was obtained on treatment of I with acetic anhydride-pyridine (2 : 1) at 100°for 3 hr and subsequent purification of the product by recrystallization. Ammonolysis of V provided a dioscin monoacetate (VI), mp 285-289° (decomp.), [α]_D-101.2° (pyridine), which was proved to be 2-O- and 4-O-bis-a-L-rhamnopyranosyl-(3-O-acetyl)-β-D-glucopyranoside of diosgenin.

• 公益社団法人日本薬学会の論文
• 1968-09-25

著者

• 川崎 敏男

  Faculty of Pharmaceutical Sciences of Kyushu University

• 川崎 敏男

  Faculty Of Pharmaceutical Sciences Kyushu University

• 山内 辰郎

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 山内 辰郎

  Faculty Of Pharmaceutical Sciences Fukuoka University

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