Trypanocidal Constituents in Plants 3. Leaves of Garcinia intermedia and Heartwood of Calophyllum brasiliense(Pharmacognosy)

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概要

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• The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and l,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.

• 公益社団法人日本薬学会の論文
• 2004-01-01

著者

• 岡部 光

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 阿部 フミ子

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 赤羽 啓栄

  福岡医大

• 赤羽 啓栄

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  九州大学 寄生虫

• 赤羽 啓栄

  信州大・志賀高原生研

• 赤羽 啓栄

  福岡大学 病理学

• ABE Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• NAGAFUJI Shinya

  Faculty of Pharmaceutical Sciences, Fukuoka University

• OKABE Hikaru

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Okabe Hikaru

  Faculty Of Pharmaceutical Sciences Fukuoka University

• 岡部 光

  福岡大学

• Okabe Hikaru

  福岡大学 薬学部

• 岡部 光

  福岡大学薬学部

• Akahane H

  School Of Medicine Fukuoka University

• 赤羽 啓栄

  福岡大医

• Abe Fumiko

  Faculty Of Pharmaceutical Science Fukuoka University

• Reyes-chilpa Ricardo

  Instituto De Quimica Universidad Nacional Autonoma De Mexico Ciudad Universitaria

• Reyes-chilpa Ricardo

  Hiv

• Estrada-muniz Elizabeth

  Institute Of Chemistry National University Of Mexico

• AKAHANE Hiroshige

  Fukuoka University School of Medicine

• HUERTA-REYES Maira

  Institute of Chemistry, National University of Mexico

• Nagafuji Shinya

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Akahane Hiroshige

  福岡大学医学部寄生虫学

• Huerta-reyes Maira

  Institute Of Chemistry National University Of Mexico

• 赤羽 啓栄

  福岡大学 医学部 寄生虫学 教室

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