In VitroにおけるDes-Arg^9-bradykininおよびそのKininaseII水解産物のラット多核白血球遊走におよぼす影響

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Effects of bradykinin and des-Arg^9-bradykinin on rat polymorphonuclear leucocyte (PMNL) emigration were assayed by the modified Boyden chamber method. the ability of des-Arg^9-bradykinin of PMNL emigration was about one-half of that of bradykinin in the concentration range of 10^<-8>M to 10^<-6>M. The kininase II-hydrolyzate of bradykinin had only a little ability on PMNL emigration at both concentrations of 10^<-6>M and 10^<-7>M. On the other hand, the kininase II-hydrolyzate of des-Arg^9-bradykinin, and Ser-Pro-Phe, which is a hydrolyzing product of des-Arg^9-bradykinin by this enzyme, induced the PMNL emigration at 10^<-6>M. These results suggest a possibility that des-Arg^9-bradykinin and Ser-Pro-Phe participate in PMNL emigration in inflammatory processes.
社団法人日本薬学会の論文
1984-06-25