ラット脳および末梢組織セロトニン量におよぼすDL-3-Pyridylalanineおよび5-Hydroxy-L-tryptophanの併用投与の影響

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1) Repeated administration of 5-hydroxy-L-tryptophan (5-HTP, 5,10 or 50 mg/kg/d, 7d) did not produce any further increase in brain serotonin (5-HT) content in Wistar male rats as compared with that found in animals given a single dose of 5-HTP. On the other hand, 5-HT content in peripheral tissues (liver, kidney, spleen and small intestine) increased more after the repeated administration of 5-HTP than after a single dose of this compound. The accumulation of 5-HT in these tissues increased with an increase in the dosage and the number of administration times of 5-HTP. 2) Brain 5-HT content increased more and maintained a high level by the combined administration of DL-3-pyridylalanine (3-PA, 100 mg/kg) with 5-HTP (5 or 10 mg/kg) than by the single administration of these compounds ; the effect was additive. Liver, kidney, spleen and small intestine 5-HT contents after the combined administration of 3-PA and 5-HTP were not different from those after the single administration of 5-HTP. 3) The efficacy of combined administration of 3-PA and 5-HTP was further confirmed by the results of the determination of tryptophan (Trp)-5-HT metabolizing enzyme activities (Trp pyrrolase, Trp 5-hydroxylase, 5-HTP decarboxylase and monoamine oxidase) and pharmacological experiment (conditioned avoidance response) in rats given these compounds. 4) Data are discussed in relation to the side effect of 5-HTP for the treatment of depression.
公益社団法人日本薬学会の論文
1983-05-25

ラット脳および末梢組織セロトニン量におよぼすDL-3-Pyridylalanineおよび5-Hydroxy-L-tryptophanの併用投与の影響

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