Effect of dl-3-Pyridylalanie on Serotonin Concentration and Tryptophan-Serotonin Metabolizing Enzymes in Rats
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概要
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A single administration of dl-3-pyridylalanine (3-PA, 100 mg/kg) significantly increased brain and serum serotonin (5-HT) concentrations without affecting the other tissue 5-HT concentrations (liver, kidney, spleen and small intestine) in male Wistar rats. The increase in brain 5-HT upon 3-PA administration was maintained for a long time (at least 96 h). Chronic administration of 3-PA (100 mg/kg/d) produced no change in brain 5-HT concentration as compared with that found in animals given a single dose of 3-PA. 3-PA decreased liver tryptophan pyrrolase (TP) activity and increased free tryptophan concentration in the serum. 3-PA hardly affected tryptophan 5-hydroxylase, 5-hydroxy-L-tryptophan (5-HTP) decarboxylase and monoamine oxidase (MAO) activities in the brain and liver. These findings suggest that the increase in brain 5-HT concentration upon administration of 3-PA occurs via the inhibition of liver TP, and an increase in free tryptophan concentration in the serum may be the causative factor for the increased brain 5-HT concentration. In contrast with 5-PA, 5-HTP (50 mg/kg, 10 mg/kg) increased the 5-HT concentrations of all tissues studied, and the brain 5-HT concentration fell to control (saline-treated) levels within several hours after the administration of 5-HTP (10 mg/kg, 6 h ; 50 mg/kg, 24 h). 5-HTP decreased brain tryptophan 5-hydroxylase and 5-HTP decarboxylase activities, and increased brain MAO and liver TP activities at 2 h after the administration.
- 公益社団法人日本薬学会の論文
- 1981-10-25
著者
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占野 廣司
Faculty of Pharmaceutical Sciences, Kyushu University
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永松 淳雄
Faculty of Pharmaceutical Sciences, Fukuoka University
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永松 淳雄
福岡大学薬学部
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戸田 晶久
久光製薬株式会社開発本部研究所
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福元 洋子
Faculty of Pharmaceutical Sciences, Fukuoka University
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戸田 晶久
Faculty of Pharmaceutical Sciences, Fukuoka University
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占野 広司
福岡大学 薬 生化
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占野 廣司
Faculty Of Pharmaceutical Sciences Fukuoka University
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永松 淳雄
Faculty Of Pharmaceutical Sciences Fukuoka University
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福元 洋子
Faculty Of Pharmaceutical Sciences Fukuoka University
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