Studies on Anti-Plasminic Agents

概要

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It was shown that dilauroyl- and dimyristoyl-L-lysine were more powerful inhibitors than the other fattyacyl derivatives of L-lysine in the proteolytic system of plasmin. In the case of carbon atom number of fattyacyl radical, upon increasing of carbon atom number the inhibitory activity was enhanced to maximum at the C-12 acyl radical, however, higher homologs decreased the inhibitory activity gradually. The inhibitory effect of dilauroyl-L-lysine given to rabbits intravenously was more remarkable than that of ε-aminocaproic acid when the effect was examined by the streptokinase activation test of blood samples taken at various intervals. Reversal by dilauroyl-L-lysine of the accelerated fibrinolysis in circulatroy rabbit blood produced by streptokinase was demonstrated. Dicarbobenzoxy-L-lysine and dilauroyl-L-lysine were shown to be potent antiinflammatory compounds. These compounds were intravenously active as the inhibitor of extravasation of trypan blue in a localized skin area of the rabbit, where the lung extract was injected intracutaneously.
公益社団法人日本薬学会の論文
1968-02-25