Anti-inflammatory Activities of Pyridylalanine Analogues and Their Influences on the Anti-inflammatory Action of Cortisone

概要

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1) Anti-inflammatory activities of pyridylalanine analogues were more potent than phenylbutazone (PB) in the carrageenin-induced rat paw edema test. dl-3-Pyridylalanine (3-PA) was 3 times more active than dl-2-pyridylalanine (2-PA) and 4 times more active than dl-4-pyridylalanine (4-PA) in this test. 2) The effects of PA analogues on the development of granuloma were studed in adrenalectomized rats by the cotton pellet medthod. 2-PA reduced the development of granuloma when given singly to rats. A simultaneous administration of 2-PA with cortisone clearly enhanced the anti-granulomatous action of cortisone. A single administration of 3-PA did not affect the development of granuloma, while a simultaneous administration of 3-PA with cortisone inhibited the action of cortisone. 4-PA had no effect on the action of cortisone and it did not affect the granuloma formation when administered alone. 3) The effects of PA analogues on the exudation were examined by the granuloma pouch method, using non-adrenalectomized rats. Among the PA analogues, only 2-PA showed a significant anti-exudative action when given singly to rats. The action of 2-PA was more active than that of PB, but less active than cortisone. The action of cortisone was enhanced by 2-PA, however, hardly affected by simultaneous administration of 3-PA or 4-PA.
公益社団法人日本薬学会の論文
1977-11-25