Metabolism of Drugs. LXX. Further Study on Antipyrine Metabolism
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概要
- 論文の詳細を見る
In the previous paper, it was shown that antipyrine was oxidized not only to 4-hydroxyantipyrine, but also to 3-hydroxymethyl-2-methyl-1-phenyl-3-pyrazolin-5-one which was characterized on the basis of analytical and spectral data. The present study established the latter pathway, the oxidation of methyl group at 3-position of pyrazolinone ring by the chemical synthesis of authentic sample, and also demonstrated chromatographically the subsequent pathway to 2-methyl-1-phenyl-5-oxo-3-pyrazolin-3-carboxylic acid. Possible importance of this serial oxidation steps was discussed concerning with antipyrine allergy problem. By the preliminary test it was shown that 3-hydroxymethyl metabolite did not retain the antipyretic acitivity.
- 社団法人日本薬学会の論文
- 1971-01-25
著者
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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占野 廣司
Faculty of Pharmaceutical Sciences, Kyushu University
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占野 廣司
九州大学薬学部
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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占野 廣司
Faculty Of Pharmaceutical Sciences Fukuoka University
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