Metabolism of Drugs. LXXVI. The Metabolic Fate of Prolintane in Rabbits
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概要
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The metabolism of prolintane (1-phenyl-2-pyrrolidinopentane hydrochloride) in rabbits has been performed in this study. Rabbits receiving the drug in oral dose of 270 mg/kg or 170 mg/kg excreted seven metabolites together with a trace of unchanged drug in the 24 hr urine. They were shown to be lactam, phenol, alcohol, lactam phenol, diastereoisomeric two lactam alcohols and amino acid, by infrared, nuclear magnetic resonance and mass spectra. Some of these were unequivocally identified by comparison with authentic samples. From these results, it is concluded that the major metabolic oxidation occured at pyrrolidine and aromatic ring to form lactam and phenolic metabolites, respectively. Penultimate oxidation of alkyl chain was seemed to be the minor reaction.
- 公益社団法人日本薬学会の論文
- 1972-09-25
著者
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吉原 新一
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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吉村 英敏
Faculty of Pharmaceutical Sciences, Kyushu University
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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吉原 新一
Faculty of Pharmaceutical Sciences, Kyushu University
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