Binding of Nitrofuran Derivatives to Nucleic Acids and Protein
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概要
- 論文の詳細を見る
1) The in vitro reduction of ^<14>C-2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2) and ^<14>C-nitrofurazone by xanthine oxidase-hypoxanthine resulted in the formation of their active metabolites capable of binding to desoxyribonucleic acid (DNA), ribonucleic acid (RNA) and protein. 2) The distribution and excretion of radioactivity in various tissues, gastrointestinal contents, feces and urine were examined after oral administration of ^<14>C-AF-2 to rats. 3) The in vivo binding of ^<14>C-AF-2 and ^<14>C-nitrofurazone to liver protein, DNA and ribosomal RNA, and to kidney protein was demonstrated in rats given orally these drugs.
- 公益社団法人日本薬学会の論文
- 1977-11-25
著者
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辰己 淳
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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辰己 淳
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Faculty of Pharmaceutical Sciences, Kyushu University
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北村 繁幸
広島大学 総合薬
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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北村 繁幸
Faculty of Pharmaceutical Sciences, Kyushu University
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