Metabolism of Drugs. LXXIX. The Metabolic Fate of Nitrofuran Derivatives. (2). Degradation by Small Intestinal Mucosa and Absorption from Gastrointestinal Tract

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The factors influencing the absorption of nitrofuran derivatives from the rat gastrointestinal tract were examined using ^<14>C-labeled AF-2,NF-161 and Nitrofurazone, and the following results were obtained.1) The in vivo and in vitro studies revealed that the above compounds were degraded mainly in the mucosa of rat small intestine. 2) The in vivo absorption rate from the gastrointestinal tract and the in vitro permeability in everted sacs were lower in the degraded products than in the parent compounds. 3) In the case of ^<14>C-NF-161,its solubility in the gastrointestinal tract affected partly the absorption rate of radioactivity. From these results, it may be concluded that when ^<14>C-nitrofuran derivatives are given to rat orally, the absorption rate of the radioactivity from the gastrointestinal tract has close relationship with the degradation of these compounds in the small intestinal mucosa, and in some cases with the solubility in the gastrointestinal tract.
公益社団法人日本薬学会の論文
1973-01-25