Metabolism of Drugs. LXXXVI. The Metabolic Fate of Nitrofuran Derivatives. (4). The Portal Absorption of Nitrofuran Derivatives and the Absorption Rate as a Function of Age in Rats
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概要
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The absorption route of ^<14>C-AF-2 (2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide) and ^<14>C-nitrofurazone (5-nitro-2-furfural semicarbazone) was examined with thoracic duct or portal vein cannulated rats. As a result, it was found that the radioactivity was almost exclusively absorbed via portal system from intestinal tract after administration of the above labeled compounds to rats. In addition, the present study revealed the direct evidences concerning the metabolism of the above nitrofuran derivatives in the intestinal mucosa of rats and the absorption of their metabolites from the intestinal wall. Further-more, it was demonstrated that the absorption rate of radioactivity was lower in 7 weeks old rats than in over 8 weeks old rats after oral administration of ^<14>C-AF-2 and ^<14>C-NF-161 (2-amino-5-[2-(5-nitro-2-furyl)-1-(2-furyl) vinyl]-1,3,4-oxadiazole).
- 公益社団法人日本薬学会の論文
- 1975-07-25
著者
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辰己 淳
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Faculty of Pharmaceutical Sciences, Kyushu University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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山口 敏朗
Faculty of Pharmaceutical Sciences, Kyushu University
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山口 敏朗
Faculty Of Pharmaceutical Sciences Kyushu University
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