Spectral Interaction of 11-Hydroxy-Δ^8-tetrahydrocannabinol with Rabbit and Rat Liver Microsomal Cytochrome P-450
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概要
- 論文の詳細を見る
11-Hydroxy-Δ^8-tetrahydrocannabinol, which is an active metabolite of Δ^8-tetrahydrocannabinol, produced a spectral change on interacting with liver microsomes of rabbits and rats (λ_<max> 395 nm ; λ_<min> 428 nm). The apparent dissociation constants (Ks) were found to be 402.1 and 76.6 μM for microsomes of untreated rabbits and rats, respectively. Pretreatment with phenobarbital enhanced the spectral change caused by 11-hydroxy-Δ^8-tetrahydrocannabinol with microsomes of both species, as well as increasing the cytochrome P-450 content. Furthermore, 11-hydroxy-Δ^8-tetrahydrocannabinol interfered with the spectral change caused by Δ^8-tetrahydrocannabinol or hexobarbital, but not with that caused by aniline. These results are consistent with the view that 11-hydroxy-Δ^8-tetrahydrocannabinol is further metabolized by the microsomal monooxygenase system involving cytochrome P-450.
- 公益社団法人日本薬学会の論文
- 1980-06-25
著者
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吉村 英敏
中村学園大学
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小栗 一太
九州大学薬学部衛生化学裁判化学教室
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小栗 一太
Faculty of Pharmaceutical Sciences, Kyushu University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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渡辺 和人
Faculty of Pharmaceutical Sciences, Hokuriku University
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Yoshimura H
Department Of Food And Nutrition Nakamura Gakuen University
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