Formation of p-Hydroxycocaine from Cocaine by Hepatic Microsomes of Animals and Its Pharmacological Effects in Mice
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概要
- 論文の詳細を見る
The hepatic microsomal metabolism of cocaine and the pharmacological effects of some metabolites were studied in experimental animals. Hepatic microsomes from mice, rats and guinea pigs catalyzed the oxidation of cocaine to m- and p-hydroxycocaines. Only trace amounts of m-hydroxycocaine were detected in the extract of the incubation mixture with rabbit hepatic microsomes. The total amount of the two hydroxycocaines was less than 12% that of norcocaine which was the most predominant microsomal metabolite in all the animal species examined. The administration of p-hydroxycocaine (20 mg/kg i.p.) to mice significantly increased locomotor activity (total distance and number of rearing movements). The effect of p-hydroxycocaine was more active or comparable with that of cocaine, indicating that this metabolite is an active metabolite of cocaine.
- 1993-10-15
著者
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吉村 英敏
中村学園大学
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渡辺 和人
北陸大学薬学部
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渡辺 和人
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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松永 民秀
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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山本 郁男
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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吉村 英敏
Department of Food and Nutrition, Nakamura Gakuen University
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松永 民秀
北陸大学薬学部衛生化学教室
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樋田 洋子
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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樋田 洋子
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Yoshimura H
Department Of Food And Nutrition Nakamura Gakuen University
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吉村 英敏
Department Of Food And Nutrition Nakamura Gakuen University
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