Potentiating Effects of N^1,N^3-Diallyluracil, N^1,N^3-Diallylthymine and N^1,N^3-Diallyl-6-methyluracil on Pentobarbital-Induced Sleep and Diazepam-Induced Motor Incoordination(Pharmacological,Chemical)

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概要

• 論文の詳細を見る

• N-Allyl derivatives of uracil(U), thymine(T) and 6-methyluracil(6-MU) were prepared, and their pharmacological activities (hypnotic activity and anticonvulsant activity against pentylenetetrazol(PTZ)-induced seizures) and interactions with three sedative-hypnotics [pentobarbital(PB), barbital(B) and diazepam(DZ)] were investigated in mice. N^1,N^3-Diallyluracil(DAU) alone exhibited hypnotic and anticonvulsant activities. None of the other allyl derivatives showed both pharmacological activities. As regards interactions, most of the compounds tested prolonged PB-induced sleep at either 80 or 160mg/kg, i.p. Further, U, T, and 6-MU (160mg/kg, i.p.) also prolonged the PB-induced sleeping time. DAU showed a prolonging effect on PB-induced sleep when given by intracerebroventricular(i.c.v.) injection. DAU, N^1,N^3-diallylthymine(DAT) and N^1-monoallyluracil(N^1-MAU) significantly prolonged the B-induced sleeping time at a dose of 160mg/kg, i.p. Further, DAU and DAT (40mg/kg, i,p.) enhanced DZ-induced motor incoordination. These results indicate that U and related compounds possess central nervous system (CNS)-depressant effects and DAU is the most potent among the N-allyl derivatives tested.

• 公益社団法人日本薬学会の論文
• 1987-12-25

著者

• 渡辺 和人

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 山本 郁男

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 木村 敏行

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• HO Ing

  University of Mississippi Medical Center

• HO Ing

  Department of Pharmacology and Toxicology, University of Mississippi Medical Center

• 舘岡 裕二

  Shinshin Chemical Industry Co. Ltd.

• Ho Ing

  ミシシッピ大学医学部薬毒理学教室

• Ho Ing

  Department Of Pharmacology & Toxicology University Of Mississippi Medical Center

• Tateoka Yuji

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 舘岡 裕二

  Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University

• 舘岡 裕二

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

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