Synthesis of 8α, 9α- and 8β, 9β-Epoxyhexahydrocannabinols
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概要
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8α, 9α- (IIa) and 8β, 9β-epoxyhexahydrocannabinol (IIIa) were prepared from Δ^3-tetrahydrocannabinol (Ia) by three reaction steps. Epoxidation of acetylated Ia with m-chloroperbenzoic acid gave a mixture of 8α, 9α- and 8β, 9β-epoxyacetates. By treatment of the mixture with lithium aluminum hydride, IIa and IIIa were prepared in 27.3 and 18.2% yields, respectively. Mass and proton nuclear magnetic resonance spectra data for IIa and IIIa are also presented.
- 公益社団法人日本薬学会の論文
- 1981-11-25
著者
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成松 鎮雄
千葉大・薬
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渡辺 和人
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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山本 郁男
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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吉村 英敏
Department of Food and Nutrition, Nakamura Gakuen University
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成松 鎮雄
岡山大・薬・衛生化学
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成松 鎭雄
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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成松 鎮雄
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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Narimatsu S
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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成松 鎮雄
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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吉村 英敏
Department Of Food And Nutrition Nakamura Gakuen University
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