A New Metabolite of 2,4,3', 4'-Tetrachlorobiphenyl in Rat Feces
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概要
- 論文の詳細を見る
Metabolism in vivo of 2,4,3', 4'-tetrachlorobiphenyl (TCB) was further studied using male Wistar rats. When the extract of feces of rats given TCB with chloroform was methylated and applied to gas chromatography (GC)-mass spectrometry (MS), a new metabolite was detected. The structure of this new metabplite was 4-hydroxy-2,5,3', 4'-TCB based on both its retention time in GC and comparison of the mass spectrum with that o the synthetic sample. 4-Hydroxy-2,5,3', 4'-TCB was assumed to be formed via a 4,5-oxide intermediate followed by NIH-shift of a chlorine atom at 4-position.
- 社団法人日本薬学会の論文
- 1992-12-25
著者
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埴岡 伸光
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Department of Food and Nutrition, Nakamura Gakuen University
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吉村 英敏
中村学園大・食物栄養
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古賀 信幸
Department of Food and Nutrition, Nakamura Gakuen University
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新山 綾子
Department of Food and Nutrition, Nakamura Gakuen College
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石田 忠三
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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石田 忠三
Faculty Of Pharmaceutical Sciences Kyushu University
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新山 綾子
Department Of Food And Nutrition Nakamura Gakuen College
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吉村 英敏
Department Of Food And Nutrition Nakamura Gakuen University
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