CIS-TRANS ISOMERIZATION OF A NITROFURAN AF-2 BY RAT LIVER MICROSOMAL PREPARATIONS
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概要
- 論文の詳細を見る
The enzymatic cis-trans isomerization of nitrofurans such as 3-(5-nitro-2-furyl)-2-(2-furyl) acrylamide (AF-2) has been proved to occur via the formation of the corresponding nitro anion radicals. Rat liver microsomes supplemented with NADPH exhibited the cis-trans isomerase activity toward AF-2,which is markedly inhibited by p-chloromercuribenzoic acid, but not by carbon monoxide. Purified rat liver NADPH-cytochrome c reductase supplemented with NADPH also exhibited a significant isomerase activity toward the nitrofuran, whereas purified rat liver NADH-cytochrome b_5 reductase exhibited only a little activity in the presence of NADPH or NADH. These results indicate that mainly NADPH-cytochrome c reductase is involved in the cis-trans isomerization of nitrofurans, i.e. the formation of nitro anion radicals catalyzed by rat liver microsomes.
- 社団法人日本薬学会の論文
- 1984-08-25
著者
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辰巳 淳
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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辰巳 淳
広島大・医・薬
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辰巳 淳
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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北村 繁幸
広島大・医・薬
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古賀 信幸
中村学園大・食物栄養
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北村 繁幸
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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古賀 信幸
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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北村 繁幸
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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