Metabolism of Drugs. LXXIII. The Metabolic Fate of Nitrofuran Derivatives. (1) Studies on the Absorption and Excretion

概要

論文の詳細を見る
The absorption and excretion of ^<14>C-labeled 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2), 2-amino-5 [2-(5-nitro-2-furyl)-1-(2-furyl) vinyl]-1,3,4-oxadiazole (NF-161) and 5-nitro-2-furfural semicarbazone (nitrofurazone) were examined following oral administration to rats. In the cases of AF-2 and NF-161 the radioactivity was mainly recovered in feces, whereas in the case of nitrofurazone it was found more in urine than in feces. In all the cases, the summation of the radioactivity which was excreted in urine and feces 96 hr after drug administration, was approximately equal to the administered radioactivity. It was also found that the hepatobiliary system played a considerably important role in the excretion of these labeled drugs. Considering this biliary excretion, the percentages of the radioactivity absorbed from gastrointestinal tract were calculated to be 59,33 and 88% for AF-2,NF-161 and nitrofurazone, respectively. The unchanged compounds recovered in urine, feces and bile were very small amount in all the cases. In the feces of rats given NF-161,however, about 20% of the dose was excreted unchanged.
社団法人日本薬学会の論文
1971-02-25