Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
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概要
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The urinary metabolic end-products of meprobamate (2-methyl-2-propyl-1,3-propanediol dicarbamate) in rabbits and dogs were studied. They were isolated and characterized as keto-, hydroxy-, carboxy-meprobamate and three glucuronides containing carbamate group, but in dogs keto-and carboxy-derivatives were not isolated. Of glucuronides, one was N-glucuronide conjugated with meprobamaet itself and another was ethertype glucuronide of hydroxy-meprobamate.
- 公益社団法人日本薬学会の論文
- 1962-06-25
著者
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山本 陽
Faculty of Pharmaceutical Sciences, Kumamoto University
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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吉村 英敏
Institute of Pharmaceutical Sciences, Medical Faculty, Kyushu University
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山本 陽
Faculty Of Pharmaceutical Sciences Kumamoto University
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山本 陽
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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