Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
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概要
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An enzyme system in rabbit liver homogenate oxidizes MHB to yield 3-OH-MHB and 3-keto-MHB. MHB is at first oxidized to 3-OH-MHB by a TPNH-dependent microsomal enzyme system. 3-Keto-MHB are then produced from 3-OH-MHB and both metabolites are interconvertible in the soluble fraction of the liver.
- 公益社団法人日本薬学会の論文
- 1962-08-25
著者
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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土岐 智
Faculty of Pharmaceutical Science, Fukuoka University
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土岐 智
Faculty Of Pharmaceutical Science Fukuoka University
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土岐 智
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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土岐 圭子
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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土岐 圭子
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
関連論文
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- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
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- Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).