Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
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概要
- 論文の詳細を見る
Amorphous meprobamate N-glucuronide, a metabolite of meprobamate which was reported in the previous paper was converted to crystalline sodium salt and the structure was reconfirmed to be sodium meprobamate N-mono-β-D-glucopyranosiduronate. It was also proved that ethinamate (1-ethynylcyclohexylcarbamate) formed the corresponding N-glucuronide in rabbits after dosing the drug. Therefore it could be concluded that N-glucuronide formation might be one of the metabolic pathways in animal body for the drug possessing a carbamate group, although it was not the case for urethane which decomposed almost completely in animal body.
- 公益社団法人日本薬学会の論文
- 1963-09-25
著者
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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辰巳 淳
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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辰巳 淳
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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吉村 英敏
Institute of Pharmaceutical Sciences, Medical Faculty, Kyushu University
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辰巳 淳
Institute of pharmaceutical Sciences, Hiroshima University School of Medicine
関連論文
- Metabolism of Drugs. XLIII. Comparison of Glucuronyl Transfer Activity between β-Glucuronidase and Uridine Diphosphate Transglucuronylase.
- Metabolism of Drugs. XLII. Isolation of Ester Glucuronides of p-Aminosalicylic Acid and Salicylic Acid from the Urine of Rabbits.
- Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
- Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
- Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (1).
- Metabolism of Drugs. LI. The Metabolic Fate of Alkylaryl Ethers in Rabbits
- The Occurrence of (ω-1)-Hydroxylation as the Major Metabolism of Alkylaryl Ethers in Rabbits
- Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
- Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
- Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).
- p-オキシ安息香酸エステルの体内変化
- Properties of Nitrofuran Reductases from Escherichia coli B/r
- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- CIS-TRANS ISOMERIZATION OF A NITROFURAN AF-2 BY RAT LIVER MICROSOMAL PREPARATIONS
- REDUCTION OF METHYL 5-NITRO-2-FUROATE BY XANTHINE OXIDASE : AN EVIDENCE FOR HYDROXYLAMINOFURAN FORMATION
- Metabolism of Drugs. LXXIII. The Metabolic Fate of Nitrofuran Derivatives. (1) Studies on the Absorption and Excretion
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- 第11回薬物代謝と薬効・毒性シンポジウム
- Metabolism of Drugs. LXXX. The Metabolic Fate of Nitrofuran Derivatives. (3). Studies on Enzymes in Small Intestinal Mucosa of Rat Catalyzing Degradation of Nitrofuran Derivatives
- Metabolism of Drugs. LXXIX. The Metabolic Fate of Nitrofuran Derivatives. (2). Degradation by Small Intestinal Mucosa and Absorption from Gastrointestinal Tract
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- Nitrosation of Ethyl Carbamate : Isolation of Ethyl N-Ethyl-N-nitrosocarbamate
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Detection of Morphine in Urine. II. An Improved Method by Thin-Layer Chromatography Utilizing Potassium Platinum Iodide as the Reagent for Both Coloration and Fluorescence
- ヨウ化白金酸カリウムによるモルヒネの瑩光反応ならびにその検出法への応用
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- Metabolism of Furazolidone in Eels
- METABOLIC FATE OF FURAZOLIDONE IN RATS
- 医薬品の生体内変化に関する研究(第8報)メチルヘキサビタールの生体内変化 その4 メチルヘキサビタール代謝物及び関連化合物の紫外, 赤外線吸収スペクトルについて
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- Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
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- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
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- 医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルヘキサビタール代謝物について
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- Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
- Enzymatic Oxidation of Methylhexabital
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- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.
- 医薬品の生体内変化に関する研究(第6報)メチルヘキサビタールの生体内変化 その2 メチルヘキサビタール及びノルメチルヘキサビタールのクロム酸酸化について
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