薬品の生体内変化に関する研究(第4報)p-Aminosalicylic Acidの家兎における生体内変化 その1
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概要
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The metabolic fate of PAS and Ac-PAS in rabbits was studied comparatively. About 74% of the 1g./kg. dose of PAS administered orally is excreted in the urine. Of this, 23〜60% are unchanged, 17〜42% as acetylated compounds, and 2〜3% as a glucuronide. About 1% of a 1.27g./kg. dose of Ac-PAS administered orally is deacetylated and 42〜68% is excreted in the unchanged form. PAS glucuronide was identified by means of paper chromatography. There were three unknown metabolites containing a free amino group in the urine and no increase in ethereal sulfate nor considerable decarboxylation of either PAS or Ac-PAS were observed.
- 公益社団法人日本薬学会の論文
- 1955-12-20
著者
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山本 陽
Faculty of Pharmaceutical Sciences, Kumamoto University
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塚元 久雄
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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山本 陽
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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山本 陽
Faculty Of Pharmaceutical Sciences Kumamoto University
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