Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi

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概要

• 論文の詳細を見る

• In order to elucidate the transformation processes of MHB metabolites, 3-keto-MHB, α-3-OH-MHB, and β-3-OH-MHB were administered to rabbits. 3-Keto-nor-MHB, 3-keto-MHB, and 3-OH-MHB have been identified in every case from the 24-hour urine by buffered-paper chromatography. From these and the results of quantitative studies, it is concluded that the 3-ketone and 3-hydroxyl groups in the cyclohexenyl ring are interconvertible and the equilibrium is in favor of 3-OH-MHB.

• 公益社団法人日本薬学会の論文
• 1959-07-20

著者

• 塚元 久雄

  Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University

• 塚元 久雄

  Pharmaceutical Institute, Medical Faculty, University of Kyushu

• 塚元 久雄

  Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University

• 土岐 智

  Faculty of Pharmaceutical Science, Fukuoka University

• 土岐 智

  Faculty Of Pharmaceutical Science Fukuoka University

• 土岐 智

  Pharmaceutical Institute, Medical Faculty, University of Kyushu

• 金田 旭立

  Pharmaceutical Institute, Medical Faculty, University of Kyushu

• 金田 旭立

  Pharmaceutical Institute Medical Faculty University Of Kyushu

関連論文

• Metabolism of Drugs. XLIII. Comparison of Glucuronyl Transfer Activity between β-Glucuronidase and Uridine Diphosphate Transglucuronylase.
• Metabolism of Drugs. XLII. Isolation of Ester Glucuronides of p-Aminosalicylic Acid and Salicylic Acid from the Urine of Rabbits.
• Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
• Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
• Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
• Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
• Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (1).
• Metabolism of Drugs. XXI. Isolation and Detection of Hydroxyl Derivatives from the Urine of Rabbits receiving Ethylhexabital (EHB, 5-Cyclohexenyl-5-ethylbarbituric Acid) and Normethylhexabital (Nor-MHB, 5-Cyclohexenyl-5-methylbarbituric Acid).
• Metabolism of Drugs. XII. The Effect of β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride (SKF 525-A) on the Metabolism of Ethylhexabital.
• Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
• Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
• Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).
• p-オキシ安息香酸エステルの体内変化
• Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
• Metabolism of Drugs. XIV. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (2)
• Isolation of Glucuronide of p-Aminosalicylic Acid
• Effect of Phenobarbital Derivatives on the Duration of Hexobarbital Hypnosis
• Metabolism of Drugs. XXII. The Metabolic Fate of Thiamylal. (1)
• 薬品の生体内変化に関する研究(第5報)Ethylhexabital代謝産物の排泄速度
• Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
• Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
• Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
• 医薬品の生体内変化に関する研究(第8報)メチルヘキサビタールの生体内変化 その4 メチルヘキサビタール代謝物及び関連化合物の紫外, 赤外線吸収スペクトルについて
• Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
• Metabolism of Drugs. XXX. The Biotransformation of Drugs having Cyclohexene Ring. (3). The Synthesis and Metabolism of 5-Ethyl-5-(1-cyclohexenyl)-4,6-dioxohexahydropyrimidine.
• Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
• Metabolism of Drugs. XXIV. Biotransformation of Drugs having Cyclohexene Ring. (1). Synthesis of Cyclohexenylglutarimide Derivatives.
• Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
• Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
• 薬品の生体内変化に関する研究(第1報) : Ethylhexabital(5-Cyclohexenyl-5-ethylbarbituric Acid)の生体内変化
• Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
• Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
• Metabolism of Drugs. XVIII. : The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (8). : The Quantitative Determination of Main Biotransformation Products of Methylhexabital in the Urine of Rabbits by Ultraviolet Spectropho
• Metabolism of Drugs. XVII. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (7). Separation and Identification of Biotransformation Products of Methylhexabital in the Urine of Rabbits by Paper Chromatography.
• 医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルヘキサビタール代謝物について
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• Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
• Enzymatic Oxidation of Methylhexabital
• Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
• Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.
• 医薬品の生体内変化に関する研究(第6報)メチルヘキサビタールの生体内変化 その2 メチルヘキサビタール及びノルメチルヘキサビタールのクロム酸酸化について
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• 薬品の生体内変化に関する研究(第3報)Methylexabital(5-Cyclohexenyl-3,5-dimethyl-barbituric Acid)の生体内変化 その1

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