Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
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概要
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PABA-GA was oxidized with periodate to identify the ring structure of this compound. The dialdehyde from PABA-GA was examined by reducting it to the corresponding alcohol. The presence of glycerol instead of glyceric acid in the hydrolyzate of the resulting alcohol was established by paper chromatography and the glycerol was identified as the crystalline tris-p-nitrobenzoate. The presence of glycerol in the hydrolyzate suggested that the dialdehyde from PABA-GA exists in the cyclic form. Periodate oxidation of synthetic 2-naphthyl-β-D-glucopyranosiduronamide and 2-naphthyl-β-D-glucofuranosiduronamide was conducted to compare the two compounds in the rate of periodate consumption and the production of acid. There is a good agreement between PABA-GA and 2-naphthyl-β-D-glucopyranosiduronamide with respect to the type of periodate oxidation. In view of above findings it was surmised that PABA-GA has a pyranose configuration.
- 社団法人日本薬学会の論文
- 1962-12-25
著者
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吉田 和夫
Daiichi College Of Pharmaceutical Sciences
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加藤 敬太郎
九州大学薬学部
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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加藤 敬太郎
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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吉田 和夫
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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Kato Keitaro
Division Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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