Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
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概要
- 論文の詳細を見る
The ester-type glucuronide of p-hydroxybenzoic acid was isolated as two derivatives from the urine of rabbits receiving p-hydroxybenzoic acid and their structures were established as methyl (p-methoxybenzoyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid) uronate and methyl (p-acetoxybenzoyl 2,3,4-tri-O-acetyl-β-D-glucopyranosid) uronate. When feeding p-hydroxybenzoic acid to rabbits, similarly as in using the methyl ester, the unchanged acid, p-hydroxyhippuric acid, the ether-type glucuronide, the estertype glucuronide, and p-carboxyphenyl sulfate were excreted as five metabolites in the urine.
- 社団法人日本薬学会の論文
- 1962-02-25
著者
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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寺田 精介
Hygienic Research Laboratory of Nagasaki Prefecture
関連論文
- Metabolism of Drugs. XLIII. Comparison of Glucuronyl Transfer Activity between β-Glucuronidase and Uridine Diphosphate Transglucuronylase.
- Metabolism of Drugs. XLII. Isolation of Ester Glucuronides of p-Aminosalicylic Acid and Salicylic Acid from the Urine of Rabbits.
- Metabolism of Drugs. XLVI. Behavior of 2-Naphthyl β-D-Glucofuranosiduronic Acid toward β-Glucuronidase.
- Metabolism of Drugs. XLV. Synthesis of 2-Naphthyl β-D-Glucofuranosiduronic Acid.
- Metabolism of Drugs. XLIV. Glucuronyl Transfer Reaction catalyzed by β-Glucuronidase by the Use of Ester Glucuronides as Substrates.
- Metabolism of Drugs. XXXIV. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (2).
- Metabolism of Drugs. XXXIII. Studies on the Ring Structure of p-Aminobenzoyl Glucuronide isolated from the Urine of Dog administered with p-Aminobenzoic Acid. (1).
- Metabolism of Drugs. XLVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (4)
- Metabolism of Drugs. XXVII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (3).
- Metabolism of Drugs. XXVI. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit. (2).
- p-オキシ安息香酸エステルの体内変化
- Synthesisof p-Nitrophenyl β-D-Glucopyranosiduronic Acid and Its Utilization as a Substrate for the Assay of β-Glucuronidase Activity
- Metabolism of Drugs. XXXV. Metabolic Fate of Meprobamate. (3). A New Metabolic Pathway of Carbamate Group : The Formation of Meprobamate N-Glucuronide in Animal Body.
- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
- Metabolism of Drugs. XXXVII. The Biotransformation of Drugs having Cyclohexene Ring. (4). The Metabolic Fate of 5-Cyclohexenyl-5-alkylhydantoins.
- Metabolism of Drugs. XXX. The Biotransformation of Drugs having Cyclohexene Ring. (3). The Synthesis and Metabolism of 5-Ethyl-5-(1-cyclohexenyl)-4,6-dioxohexahydropyrimidine.
- Metabolism of Drugs. XXV. Biotransformation of Drugs having Cyclohexene Ring. (2). Metabolic Fate of 2-Substituted Cyclohexenylglutarimides.
- Metabolism of Drugs. XXIV. Biotransformation of Drugs having Cyclohexene Ring. (1). Synthesis of Cyclohexenylglutarimide Derivatives.
- Metabolism of Drugs. XXIII. Metabolic Fate of p-Hydroxybenzoic Acid and its Derivatives in Rabbit.
- Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XXIX. Metabolic Fate of Meprobamate. (2). Further Studies on the Structure of the Metabolites.
- Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
- Metabolism of Drugs. XIX. Metabolic Fate of p-Aminosalicylic Acid in the Rabbit. (3).
- 薬品の生体内変化に関する研究(第4報)p-Aminosalicylic Acidの家兎における生体内変化 その1
- Metabolism of Drugs. XXXI. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (10). Enzymatic Oxidation of Methylhexabital.
- Enzymatic Oxidation of Methylhexabital
- Metabolism of Drugs. XX. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (9). Interconversion of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and 3-OH-MHB (5-(3-Hydroxy-1-cyclohexenyl)-3,5-dimethylbarbi
- Detection of Hydroxyl Derivatives from the Urine of Men administered Ethylhexabital and Methylhexabital by Buffered Paper Chromatography.