Metabolism of Drugs. XXXVI. The Metabolic Fate of Thiamylal[5-Allyl-5-(1-methylbutyl)-2-thiobarbituric Acid]. (2).
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概要
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Six among eight metabolites which were detected by paper chromatography, were isolated as crystalline compounds from the urine of rabbits administered thiamylal and all their structures were established as thiamylal ω-carboxylic acid, unchanged thiamylal, secobarbital, (ω-1)-hydroxythiamylal, secobarbital ω-carboxylic acid, and (ω-1)-hydroxysecobarbital, respectively. The fate of thiamylal ω-carboxylic acid, the main metabolite of thiamylal, was also studied and the possible in vivo metabolic map of thiamylal was speculated.
- 公益社団法人日本薬学会の論文
- 1963-04-25
著者
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塚元 久雄
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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塚元 久雄
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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井出 博之
Facutly Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Institute of Pharmaceutical Sciences, Medical Faculty, Kyushu University
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井出 博之
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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三井 勝允
Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
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三井 勝允
Institute Of Pharmaceutical Sciences Faculty Of Medicine Kyushu University
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