医薬品の生体内変化に関する研究(第8報)メチルヘキサビタールの生体内変化 その4 メチルヘキサビタール代謝物及び関連化合物の紫外, 赤外線吸収スペクトルについて
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概要
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The ultraviolet absorption spectra of the metabolites from the urine of rabbits receiving MHB, the oxidation products of MHB and nor-MHB with chromium trioxide were measured, and the relation between these compounds and their structures was discussed. The infrared absorption spectra of 3-keto-MHB and MHB-M (II) from the previous work in this series indicated that the two are completely identical and would be α, β-unsaturated ketones and that of 3-OH-MHB suggested the existence of a hydroxyl group in the structure.
- 1956-10-25
著者
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塚元 久雄
Pharmaceutical Institute, Medical Faculty, University of Kyushu
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Pharmaceutical Institute Medical Faculty University Of Kyushu
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土岐 智
Faculty of Pharmaceutical Science, Fukuoka University
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土岐 智
Faculty Of Pharmaceutical Science Fukuoka University
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土岐 智
Pharmaceutical Institute, Medical Faculty, University of Kyushu
関連論文
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- Metabolism of Drugs. XII. The Effect of β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride (SKF 525-A) on the Metabolism of Ethylhexabital.
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- The Occurrence of (ω-1)-Hydroxylation as the Major Metabolism of Alkylaryl Ethers in Rabbits
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- Metabolism of Drugs. XXXIX. Further Studies on Carbamate N-Glucuronide Formation in Animal Body.
- Metabolism of Drugs. XV. Isolation and Paper Chromatography of Urinary Glucuronide of Salicylic Acid in the Rabbit.
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- ヨウ化白金酸カリウムによるモルヒネの瑩光反応ならびにその検出法への応用
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- 医薬品の生体内変化に関する研究(第8報)メチルヘキサビタールの生体内変化 その4 メチルヘキサビタール代謝物及び関連化合物の紫外, 赤外線吸収スペクトルについて
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- Metabolism of Drugs. XXXII. The Metabolic Fate of Secobarbital [5-Allyl-5-(1-methylbutyl) barbituric Acid].
- Metabolism of Drugs. XIII. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (5). Further Studies on Isolation, Characterisation, and Identification of Biotransformation Products of the Drug excreted in the Urine of Rabbi
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- 薬物代謝と毒性
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- Metabolism of Drugs. XXVIII. Metabolic Fate of Meprobamate. (1). Isolation and Characterization of Metabolites.
- Metabolism of Drugs. XVIII. : The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (8). : The Quantitative Determination of Main Biotransformation Products of Methylhexabital in the Urine of Rabbits by Ultraviolet Spectropho
- Metabolism of Drugs. XVII. Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (7). Separation and Identification of Biotransformation Products of Methylhexabital in the Urine of Rabbits by Paper Chromatography.
- 医薬品の生体内変化に関する研究(第7報)メチルヘキサビタールの生体内変化 その3 メチルヘキサビタール代謝物について
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- Enzymatic Oxidation of Methylhexabital
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