Metabolism of Drugs. XVI. The Metabolic Fate of Methylhexabital (5-Cyclohexenyl-3,5-dimethylbarbituric Acid). (6). Studies on the Reduction of 3-Keto-MHB (5-(3-Oxo-1-cyclohexenyl)-3,5-dimethylbarbituric Acid) and on Pharmacological Activity of the Biotran
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概要
- 論文の詳細を見る
Two isomeric hydroxyl compounds, m.p. 213〜215°(decomp.) and m.p. 143〜143.5°, were obtained by reduction of 3-keto-MHB (5-(3-oxo-1-cyclohexenyl)-3,5-dimethylbarbituric acid) and those were identical in all respects with the amjor urinary metabolites, the diastereoisomeric (+)-α-and (+)-β-3-OH-MHB (5-(3-hydroxy-1-cyclohexenyl)-3,5-dimethylbarbituric acid), respectively, except the optical property. Pharmacological activity of four main metabolites of MHB obtained previously were also examined but none showed any hypnotic action.
- 公益社団法人日本薬学会の論文
- 1958-02-20
著者
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吉村 英敏
Faculty of Pharmaceutical Sciences, Kyushu University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Pharmaceutical Institute Medical Faculty University Of Kyushu
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