Studies on the Metabolic Relationship between Alkyl Carbamates and Alkyl N-Hydroxycarbamates in Rats

概要

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When methyl, ethyl or n-propyl N-hydroxycarbamate was administered to rats intraperitoneally, the corresponding alkyl carbamate was detected as a urinary metabolite by thin-layer chromatography. These alkyl N-hydroxycarbamates were also converted to the corresponding alkyl carbamates by rat liver slices, but not by rat liver 9000 g supernatant. This suggests that the reduction of alkyl N-hydroxycarbamates may be catalyzed by liver enzymes which are different in nature from aromatic hydroxylamine-reducing enzymes. Similarly, the metabolism of ethyl carbamate in rats was investigated in vivo and in vitro. However, no ethyl N-hydroxycarbamate could be detected in these experiments. Therefore, it appears unlikely that alkyl N-hydroxycarbamates are metabolites of the corresponding alkyl carbamates in rats.
公益社団法人日本薬学会の論文
1980-01-25