Grignard Reaction and Products. V. Reduction of Ketoximes to Aziridines with Grignard Reagents
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概要
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For the purpose of expanding our former finding that cyclohexylmagnesium chloride acted as reductive reagent to convert a ketoxime to an aziridine, following ten ketoximes were treated with cyclohexylmagnesium chloride or isobutylmagnesium bromide : Oximes (4-13) of dibenzyl ketone, phenyl benzyl ketone, 2-benzhydrylcyclohexanone, 2-benzoylcyclohexanone, 2-(1-phenyl) cyclohexylcyclohexanone, propiophenone, 4-phenyl-4-methyl-pentan-2-one, cyclohexanone, benzophenone and camphor. By this treatment, ketoximes (4-10) suffered reduction to be converted to aziridines. Among those, the cases of 9 and 10 were accompanied with Hoch-Campbell reaction. 12 and 13 were converted to ketimines by the same treatment.
- 公益社団法人日本薬学会の論文
- 1976-05-25
著者
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田口 胤三
Faculty of Pharmaceutical Sciences, Kyushu University
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川副 裕一
Faculty of Pharmaceutical Sciences, Kyushu University
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今井 清
Faculty Of Pharmaceutical Sciences Kyushu University
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川副 裕一
Faculty Of Pharmaceutical Sciences Kyushu University
-
田口 胤三
Faculty Of Pharmaceutical Sciences Kyushu University
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