Grignard Reaction and Products. II. A Novel Intramolecular Cyclization in the Grignard Reaction of Alicyclic Ketoxime containing an Aromatic Nucleus
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概要
- 論文の詳細を見る
A novel intramolecular cyclization reaction was found in the reaction of 2 (1'-phenyl)-cyclohexylcyclohexanone oxime (I-oxime) with aromatic Grignard reagent, either phenyl- or p-tolylmagnesium bromide, which worked as a catalyst. The reaction required at least 3 equivalent moles of Grignard reagent. The structure of the cyclization product (II) was established as spiro [bicyclo [3.3.1]-3,4-benzononan-9-one-2,1'-cyclohexane]. The structural feature of oximes which suffer the cyclization reaction was preliminary discussed.
- 公益社団法人日本薬学会の論文
- 1970-09-25
著者
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田口 胤三
Faculty of Pharmaceutical Sciences, Kyushu University
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田口 胤三
Faculty Of Pharmaceutical Sciences Kyushu University
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宮野 和子
Faculty of Pharmaceutical Sciences, Kyushu University
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宮野 和子
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)faculty Of Pharmacy Fukuoka Un
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