Grignard Reaction and Products. I. 1,4-Addition of Arylmagnesium Bromide to 2-Alkylidenecyclohexanone and the Oxidative Cleavage therein
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概要
- 論文の詳細を見る
Phenylmagnesium bromide reacted with 2-cyclohexylidenecyclohexanone (I) affording 2-(1-phenylcyclohexyl) cyclohexanone (II) in main, via 1,4-addition. Besides, it accompanied 6-(1-phenylcyclohexyl)-6-oxo-hexanoic acid (III) as by-product, even though the reaction was carried out in a stream of nitrogen, using purified ether as a solvent. It was found that (a) III itself did not exist just after the Grignard reaction and appeared after heating of the reaction mixture at 70-80° ; (b) the ketone II, even in the enol form, did not produce a substance which convert into III by the absorption of oxygen. This suggested that the III-precursor, presumably a peroxide, was produced in the course of the Grignard reaction, thereafter transformed to III. Reactions for the identification of III and the Grignard reaction of other α, β-unsaturated ketones were persued.
- 公益社団法人日本薬学会の論文
- 1970-09-25
著者
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田口 胤三
Faculty of Pharmaceutical Sciences, Kyushu University
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田口 胤三
Faculty Of Pharmaceutical Sciences Kyushu University
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宮野 和子
Faculty of Pharmaceutical Sciences, Kyushu University
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宮野 和子
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)faculty Of Pharmacy Fukuoka Un
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