グリニヤール反応と生成物(第3報)2位に3級炭素置換基(芳香核を含む)をもつ脂環式ケトオキシムのグリニヤール反応による分子内閉環反応

概要

論文の詳細を見る
Grignard reaction was performed it a variety of ketoximes using arylmagnesium bromides. 2-(1-Aryl or aralkyl) cyclohexylcyclohexanone oxime (1a-g) and 2-(1-methyl-1-phenyl) ethylcyclohexanone oxime (13) converted to cyclization products and 2-benzyl-, 2-(1-phenyl)propyl-, and 2-benzhydryl-cyclohexanone oximes (6a-c), 4-methyl-4-phenylpentan-2-one oxime (17), and 2-benzoylcyclohexanone oxime (20) to aziridine derivatives (Hoch-Campbell reaction products). These results showed that the cyclization occurred only in the reaction of alicyclic ketoximes substituted by a tertiary carbon radical containing an aromatic ring at C_2 position and suggested that a stereochemical factor might be responsible for this cyclization.
公益社団法人日本薬学会の論文
1974-04-25