Metabolism of Drugs. LXXX. The Metabolic Fate of Nitrofuran Derivatives. (3). Studies on Enzymes in Small Intestinal Mucosa of Rat Catalyzing Degradation of Nitrofuran Derivatives
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概要
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The enzymes responsible for the degradation of nitrofuran derivatives in rat small intestinal mucosa were examined in vitro. As a result, it was suggested that the initial reactions in the degradation of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) and 5-nitro-2-furfural semicarbazone (nitrofurazone) are mainly catalyzed by xanthine oxidase, while that of 2-amino-5-[2-(5-nitro-2-furyl)-1-(2-furyl)vinyl]-1,3,4-oxadiazole (NF-161) is catalyzed by alternative enzyme beside xanthine oxidase, too. Furthermore, the present results suggest that a part of metabolites formed from AF-2 by hypoxanthine-dependent or NADH-dependent reaction in rat small intestinal mucosa might be tightly bound to or physically adsorbed to the macromolecules of cellular constituents.
- 公益社団法人日本薬学会の論文
- 1973-03-25
著者
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辰巳 淳
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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山口 敏夫
Faculty Of Pharmaceutical Sciences Kyushu University
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辰巳 淳
Faculty of Pharmaceutical Sciences, Kyushu University
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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辰巳 淳
Institute of pharmaceutical Sciences, Hiroshima University School of Medicine
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