薬物代謝からみた中毒 (プライマリ・ケアのための急性中毒の救急初期治療<今月の課題>)
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概要
著者
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小栗 一太
九州大学薬学部衛生化学裁判化学教室
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吉村 英敏
中村学園大・食物栄養
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
関連論文
- 第23回学術年会を終えて
- 新規抗悪性腫瘍薬 S-1 の各配合成分の体内動態 (第3報) : ラットにおける S-1 反復投与時の各配合成分の吸収, 排泄および肝薬物代謝酵素系に与える影響
- β遮断薬 Bunitrolol の代謝反応における立体選択性と体内動態との関連性
- Effect of Morphine and Its Conjugates on the Isolated Ileal Preparation of Guinea-pig
- 薬物動態研究事始め(4)
- 学術貢献賞受賞 山本郁男氏の業績
- 医薬品の生体内変化に関する研究(第85報)1-p-Chlorophenyl-2,3-dimethyl-4-dimethylaminobutan-2-ol Hydrochlorideの代謝に関する研究
- Cytochrome P450 と mEH および UGTとの蛋白質相互作用
- Properties of Nitrofuran Reductases from Escherichia coli B/r
- モルモット肝UDP-グルクロン酸転移酵素 UGT2B21 および UGT2B22のcDNA クローニングとCOS-1 cell における発現 - ヘテロオリゴマー形成によるモルヒネ活性代謝物生成について -
- モルヒネの活性代謝物生成に関するモルモット肝 UDP-グルクロン酸転移酵素の cDNA クローニングについて
- モルヒネ活性代謝物生成に関与するモルモット肝UDP-グルクロン酸転移酵素について
- Identification of in Vitro Metabolites of 2,4,6,2', 4', 6'-Hexachlorobiphenyl from Phenobarbital-Treated Dog Liver Microsomes
- Synthesis and Pharmacological Evaluation in Mice of Halogenated Cannabidiol Derivatives
- Pharmacologica Efects in Mice of Anandamide and Its Related Fatty Acid Ethanolamides, and Enhancement of Cataleptogenic Effect of Anandamide by Phenylmethylsulfonyl Fluoride
- Synthesis and Pharmacological Activities in Mice of Halogenated Δ^9-Tetrahydrocannabinol Derivatives
- BrucineによるCYP2B subfamily P450の誘導:種差による検討
- フェノバルビタール型PCBのウサギ肝における代謝
- Effect of Cytochrome P450 Inducers on Liver Microsomal Metabolism of Tetrachlorobiphenyls in Rats, Guinea Pigs and Hamsters
- Metabolic Formation of Dimethylamine and Methylamine from Basic Drugs Containing N-Methyl Group : A Newly Established Chromatographic Assay and Its Application to the Determination of Deaminase Activity
- Purification and Characterization of a Morphine UDP-Glucuronyltransferase Isoform from Untreated Rat Liver
- A New Metabolite of 2,4,3', 4'-Tetrachlorobiphenyl in Rat Feces
- Synthesis and Pharmacological Activity of Sulfate Conjugates at 6-Position of N-Substituted Normorphine Derivatives
- Rat Liver DT-Diaphorase as a Nitroso-Reductase
- 覚せい剤及び関連化合物の代謝 : その生化学的側面
- Synthesis and Analgesic Effect of Normorphine-3- and -6-glucuronides
- 乱用薬物の代謝
- 駆け出しの頃(私はあの時、こう閃いた!-研究の壁を突破し、大きく飛躍するため-)
- モルヒネとヘロインの法中毒学
- Reconstitution of Apo-DT-diaphorase with Flavin-Adenine Dinucleotide
- CIS-TRANS ISOMERIZATION OF A NITROFURAN AF-2 BY RAT LIVER MICROSOMAL PREPARATIONS
- 共通一次入試と学生気質(入試制度と薬学教育)
- 薬物代謝からみた中毒 (プライマリ・ケアのための急性中毒の救急初期治療)
- REDUCTION OF METHYL 5-NITRO-2-FUROATE BY XANTHINE OXIDASE : AN EVIDENCE FOR HYDROXYLAMINOFURAN FORMATION
- Metabolism of Drugs. LXXIII. The Metabolic Fate of Nitrofuran Derivatives. (1) Studies on the Absorption and Excretion
- Metabolism of Drugs. LXX. Further Study on Antipyrine Metabolism
- Metabolism of Drugs. LXIX. Studies on the Urinary Metabolites of Morphine in Several Mammalian Species
- 医薬品の生体内変化に関する研究(第66報) : Pantethineの生体内変化について
- On the Structure of Morphine-6-glucuronide in a Solid State
- Metabolism of Drugs. LX. The Synthesis of Codeine and Morphine Glucuronides
- メチルオレンジ法によるモルヒネ定量の変法
- Microsomal Aldehyde Oxygenase (MALDO) for Tolualdehydes, Active Metabolites of Xylenes, in the Mouse Liver and Lung
- "B-4 Hydrolysis of Xenobiotics by ES46.5K, a Novel Esterase from Mouse Liver Microsomes
- Microsomal Aldehyde Oxygenase (MALDO): Purification and Characterization of a Cytochrome P450 Isozyme Responsible for Oxidation of 9-Anthraldehyed to 9-Anthracenecarboxylic Acid in Monkey Liver
- Mechanism of Inhibitory Effects of Cannabidiol and Cannabidiol Hydroxy-quinone on the Hepatic Microsomal Drug-Metabolizing Enzymes in Mice (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Involvement of a Novel Mouse Hepatic Microsomal Esterase, ES46.5K, in the Hydrolysis of Phthalate Esters
- Mechanism of Hepatic Microsomal Oxidation of 11-Hydroxy-Δ^8-tetra-hydrocannabinol to 11-Oxo-Δ^8-tetrahydrocannabinol. Evidence for Hydration of the Aldehyde Formed
- PURIFICATION AND CHARACTERIZATION OF MOUSE HEPATIC MICROSOMAL ALDEHYDE OXYGENASE
- MECHANISM OF CANNABIELSOIN FORMATION FROM CANNABIDIOL, ONE OF THE MAJOR CMPONENTS OF MARIHUANA
- CYTOCHROME P450 ISOZYMES INVOLVED IN METABOLIC ACTIVATION OF Δ^9-TETRAHYDROCANNABINOL BY RAT LIVER MICROSOMES
- Mechanism of Biological Formation of Cannabielsoin from Cannabidiol in the Guinea-Pig, Mouse, Rat and Rabbit
- HEPATIC MICROSOMAL OXYGENATION OF METHYL GROUP TO CARBOXYLIC ACID IN XENOBIOTICS : METABOLISM OF Δ^8-TETRAHYDROCANNABINOL AT THE 11-POSITION
- Identification of Cannabielsoin, a New Metabolite of Cannabidiol Formed by Guinea-Pig Hepatic Microsomal Enzymes, and Its Pharmacological Activity in Mice
- METABOLIC DISPOSITION OF 8α, 9α-AND 8β, 9β-EPOXYHEXAHYDROCANNABINOLS IN THE MOUSE
- DIFFERENCE IN EPOXIDES FORMATION AND THEIR FURTHER METABOLISM BETWEEN Δ^9 -AND Δ^8-TETRAHYDROCANNABINOLS BY HUMAN LIVER MICROSOMES
- Morphine Phosphate Estersの合成ならびに薬理作用について
- ノスカピンの生体内運命に関する研究(第1報)家兎尿中代謝物の検索
- 油症研究-この10年間の推移
- ポリ塩素化ビフェニル(PCB)と関連化合物 (環境汚染物質と毒性--有機物質編)
- Metabolism of Drugs. LXXXI. Further Studies on Metabolism of Prolintane in Rabbits
- Metabolism of Drugs. LXXVI. The Metabolic Fate of Prolintane in Rabbits
- モルモット肝臓のモルヒネ活性代謝物生成に関与する主要なUDP-グルクロン酸転移酵素について
- Anandamide, an Endogenous Cannabinoid Receptor Ligand, Also Interacts with 5-Hydroxytryptamine (5-HT) Receptor
- 医薬品の生体内変化に関する研究(第74報)メタプロテレノールの代謝について2
- 3-Methylcholanthrenceおよびantioxiantによるセレン結合性タンパク質の誘導の用量依存性について
- フェノバルビタールにより誘導される2種のモルヒネUDP-グルクロン酸転移酵素分子種
- Metabolism of Drugs. LXXV. The Enzymatic Degradation of Isoprophenamine
- Cytochrome P4502Bサブファミリーの誘導機構 : 研究進展と問題点の現状
- 乱用薬物の代謝とその機構
- 光アフィニティーリガンドによるフェノバルビタール結合性蛋白質の探索
- Phenobarbital 誘導性のモルモット肝 P450 : 分子種と遺伝子構造
- Metabolism of Drugs. LXXII. Synthesis of Nalorphine-3- and -6-glucuronide and Identification of Urinary Metabolites of Nalorphine in Rabbits
- Metabolism of Drugs. LXXX. The Metabolic Fate of Nitrofuran Derivatives. (3). Studies on Enzymes in Small Intestinal Mucosa of Rat Catalyzing Degradation of Nitrofuran Derivatives
- Metabolism of Drugs. LXXIX. The Metabolic Fate of Nitrofuran Derivatives. (2). Degradation by Small Intestinal Mucosa and Absorption from Gastrointestinal Tract
- Susceptibility of Aromatic Nitro Compounds to Xanthine Oxidase-catalyzed Reduction
- トキシコロジーと薬物代謝学(薬学におけるトキシコロジーの発展)
- オクテット
- Chemical Reactivity of Morphine and Morphine-6-conjugates and Their Binding to Rat Brain
- 医薬品の生体内変化に関する研究(第84報)Morphine Glucuronidesのウサギ, モルモットおよびマウスにおける代謝
- 医薬品の生体内変化に関する研究(第83報)Morphine Glucuronidesのラットにおける代謝
- 医薬品の生体内変化に関する研究(第77報)アンチピリンのin Vitro代謝
- INHIBITORY EFFECT OF CANNABIDIOL ON THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM IN THE RAT
- 第12回薬物代謝と薬効・毒性シンポジウム
- In Vivo Metabolism of 11-Hydroxy-Δ^8-tetrahydrocannabinol to Two Carboxylic Acids and the Effects of SKF 525-A, Cobaltous Chloride and Phenobarbital on Their Formation in Rats
- Spectral Interaction of 11-Hydroxy-Δ^8-tetrahydrocannabinol with Rabbit and Rat Liver Microsomal Cytochrome P-450
- 「座長のあり方」の前に(年会一般講演の座長のあり方)
- Morphineおよび関連化合物の抱合型代謝物とその薬効
- Synthesis of Δ^8-Tetrahydrocannabinol Glucuronide and Sulfate, and Their Metabolic Disposition in Rats
- Detection of Morphine in Urine. II. An Improved Method by Thin-Layer Chromatography Utilizing Potassium Platinum Iodide as the Reagent for Both Coloration and Fluorescence
- ヨウ化白金酸カリウムによるモルヒネの瑩光反応ならびにその検出法への応用
- Detection of Morphine in Urine
- DEAMINATION OF AMPHETAMINES BY CYTOCHROMES P450: STUDIES ON SUBSTRATE SPECIFICITY AND REGIOSELECTIVITY WITH MICROSOMES AND PURIFIED CYP2C SUBFAMILY ISOZYMES
- Induction of Bilirubin UDP-Glucuronyltransferase and P-450 4A Subfamily in Guinea Pigs by Treatment with Coplanar PCB (Proceedings of the 18th Symposium on Toxicology, and Environmental Health)
- Mechanism of Pulmonary Cytochrome P450 Inactivation by Tolualdehydes, Active Metabolites of Xylenes (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Metabolic Reaction of Tolualdehydes by Microsomal Aldehyde Oxygenase (MALDO) in Lung (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- Effect of Coplanar PCB on Gluconeogenesis and Lipid Metabolism : Comparison between Rats and Guinea Pigs (Proceedings of the 19th Symposium on Toxicology and Environmental Health)
- INHIBITION OF ANANDAMIDE AMIDASE ACTIVITY IN MOUSE BRAIN MICROSOMES BY CANNABINOIDS
- Involvement of a Novel Mouse Hepatic Esterase (ES46.5K) in the Hydrolysis of Phthalate Esters (Proceedings of the 21st Symposium on Toxicology and Environmental Health)
- Pharmaco kinetics and analgesic actions of locally retentive morphine suppository.
- 中毒原因物質の分析法 : 現状と進歩(化学物質による急性中毒 : 最近の話題, 救急救命と中毒物質の分離・同定)