Metabolism of Drugs. LXXII. Synthesis of Nalorphine-3- and -6-glucuronide and Identification of Urinary Metabolites of Nalorphine in Rabbits
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概要
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Nalorphine-3- and -6-glucuronide were synthesized according to the method used in the synthesis of morphine glucuronides. These glucuronides were then utilized as reference standards for identification of the urinary metabolites of nalorphine in rabbits, and nalorphine-3-glucuronide was established as a major metabolite. No other metabolite could be detected in the 24 hr urine samples, except a small amount of unchanged nalorphine was detected. Isolation procedure of the urinary glucuronides adopted in the present and previous studies was confirmed to be very effective especially for the morphine alkaloids.
- 公益社団法人日本薬学会の論文
- 1970-12-25
著者
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小栗 一太
九州大学薬学部衛生化学裁判化学教室
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森 正明
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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森 正明
九大・医療短大
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小栗 一太
Faculty of Pharmaceutical Sciences, Kyushu University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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