医薬品の生体内変化に関する研究(第77報)アンチピリンのin Vitro代謝
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概要
- 論文の詳細を見る
In connection with the previous in vivo work^<3,4)> that antipyrine was mainly metabolized to 4-hydroxyantipyrine and 3-hydroxymethyl-2-methyl-1-phenyl-3-pyrazolin-5-one (AN-CH_2OH), the in vitro metabolism of this drug was investigated by use of 9000×g supernatant fraction of rat liver. It was found that antipyrine was oxidized to 4-hydroxyantipyrine and AN-CH_2OH by the 9000×g supernatant of the liver. These metabolites were detected by means of thin-layer and gas chromatographies, and by ultraviolet absorption spectral analysis.
- 公益社団法人日本薬学会の論文
- 1972-11-25
著者
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吉村 英敏
中村学園大・食物栄養
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吉村 英敏
九州大学薬学部
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占野 廣司
九州大学薬学部
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Yoshimura Hidetoshi
Department Of Food And Nutrition Nakamura Gakuen University
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