大麻草の裁判化学的研究III. : 大麻成分検出法の実際鑑定への応用(2)

概要

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The previous study on marihuana smoking indicated that the addicts would inhale about half amount of three main constituents, cannabidiol (CBD), tetrahydrocannabinol (THC) and cannabinol (CBN) in marihuana cigarettes, and suggested that some of the constituents might be excreted as unchanged or conjugated forms into the urine of these addicts. The present study was undertaken to confirm this possibility using rabbits. It was found in this experiment that free marihuana constituents in urine was extracted effectively with CHCl_3 during 10 hr under the pH 3. It was also shown that treatment of the urine with either 5% HCl or β-glucuronidase was necessary for detection of marihuana constituents in the urine before the extraction. Applying these procedures, CBN was detected in the urine of rabbits injected either CBN or ganja extract which contained a considerable amount of CBN. However, the excretion of any constituent could not be confirmed in the urine of either CBD or THC treated rabbits.
社団法人日本薬学会の論文
1968-10-30