Metabolism of Drugs. L. The In Vitro Study on Metabolism of Brucine and 4-Substituted Veratroles
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概要
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Interesting selective demethylation of brucine and 4-substituted veratroles, which was found to occur as major metabolism in rabbits, was further investigated by in vitro systems. Using 9000×g. supernatant fraction of rabbit liver homogenate, it was shown that demethylation of brucine and 4-nitroveratrole was catalyzed by so called "liver microsomal drug metabolizing enzyme systems, " and it took place predominantly at the meta-position of the lactam group of brucine and at the para-position of nitro group of 4-nitroveratrole at pH 7.5,coinciding with the in vivo results.^<1,2> On the other hand, 4-acetamidoveratrole underwent mostly deacetylation by the same fraction. In addition, demethylation of 4-nitroveratrole studied further by rabbit liver microsomes, and it was found that NADH was even more effective than NADPH as the cofactor if added sufficiently to the incubation mixture.
- 公益社団法人日本薬学会の論文
- 1964-10-25
著者
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塚元 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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渡部 烈
Faculty of Pharmaceutical Sciences, Kyushu University
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渡部 烈
Biochemical Laboratory Division Of Organic Chemistry Tokyo College Of Pharmacy
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