Suppression of Liver Microsomal Drug-Metabolizing Enzyme Activities in Adult Female Rats Pretreated with Cannabidiol
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概要
- 論文の詳細を見る
The suppression by cannabidiol (CBD) of the liver microsomal drug-metabolizing enzyme activities in female rats was demonstrated and its mechanism was examined. Pretreatment of rats with CBD (10 mg/kg, i.p.) caused temporary decreases in contents of cytochrome P450 (P450) and b_5 and NADPH-cytochrome c (P450) reductase activity compared with values from the vehicle control group. p-Nitroanisole O-demethylase, aniline hydroxylase, d-benzphetamine N-demethylase and Δ^9-tetrahydrocannabinol 11-hydroxylase were also decreased by the CBD pretreatment. The latter two activities took a longer time to return to control levels than the former two. However, the CBD pretreatment, which reduced the protein level of P450 UT-2 (CYP2C11) in adult male rats, did not decrease the protein level of P450 F-1 (CYP2C6) or F-2 (CYP2C12) in liver microsomes from female rats. These results suggest that the mechanisms by which CBD suppresses liver microsomal drug-metabolizing enzyme activities are different in male and female rats.
- 公益社団法人日本薬学会の論文
- 1993-04-15
著者
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舩江 良彦
大阪市立北市民病院 麻酔科
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今岡 進
大阪市立北市民病院 麻酔科
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成松 鎮雄
千葉大・薬
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渡辺 和人
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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松永 民秀
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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山本 郁男
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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今岡 進
Laboratory of Chemistry, Osaka City University Medical School
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成松 鎮雄
岡山大・薬・衛生化学
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成松 鎭雄
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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吉村 英敏
Faculty Of Pharmaceutical Sciences Kyushu University
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松永 民秀
北陸大学薬学部衛生化学教室
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成松 鎮雄
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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船江 良彦
Laboratory Of Chemistry Osaka City University Medical School
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舩江 良彦
Laboratory of Chemistry, Osaka City University Medical School
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Narimatsu S
Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University
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成松 鎮雄
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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