Comparison of Pharmacological Effects of Tetrahydrocannabinols and Their 11-Hydroxy-Metabolites in Mice

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概要

• 論文の詳細を見る

• Pharmacological effects (catalepsy, hypothermia, pentobabrital-induced sleep prolongation, anticonvulsant and analgesic effects) of Δ^8- and Δ^9-tetrahydrocannabinols, and their 11-hydroxy-metabolites were evaluated and compared in mice Δ^9-Tetrahydrocannabinol and 11-hydroxy-Δ^9-tetrahydrocannabinol exhibited somewhat greater effects than did Δ^8-tetrahydrocannabinol and 11-hydroxy-Δ^8-tetrahydrocannabinol, respectively, in all pharmacological indices tested. Greater effects of 11-hydroxy-metabolites than those of tetrahydrocannabinols were also demonstrated.

• 公益社団法人日本薬学会の論文
• 1990-08-25

著者

• 成松 鎮雄

  千葉大・薬

• 渡辺 和人

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 山本 郁男

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 吉村 英敏

  Department of Food and Nutrition, Nakamura Gakuen University

• 成松 鎮雄

  岡山大・薬・衛生化学

• 成松 鎭雄

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• 西上 潤

  Department of Legal Medicine, Kanazawa University Faculty of Medicine

• 成松 鎮雄

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 木島 貴子

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 西上 潤

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 木島 貴子

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• Yoshida H

  Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.

• Narimatsu S

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• 成松 鎮雄

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 吉村 英敏

  Department Of Food And Nutrition Nakamura Gakuen University

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