Synthesis and Pharmacological Effects in Mice of Halogenated Cannabinol Derivatives
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概要
- 論文の詳細を見る
Eight halogenated drivatives of cannabinol (CBN) substituted on the aromatic ring at the 2 and/or 4 position were synthesized and their pharmacological effects were evaluated by intracerebroventricular injection (50 μg/mouse)in mice, using hypothermia, pentobarbital-induced sleep prolongation, catalepsy and anticonvulsant effect as indices.The hypothermic effects of monohalogenated drivatives of CBN were comparable to that of CBN, whereas the effects of dihalogenated derivatives of CBN except for the fluorinated derivative were attenuated. In the interaction with pentobarbital, two monochlorinated derivatives exhibited a significant prolongation of sleeping time, although other derivatives did not significantly affect the sleeping time. The cataleptogenic effects of monofluoro- and 4-bromo-CBN were stronger than that of CBN. 4-Bromo-CBN exhibited a significant prolongation of seizure latency induced by pentylenetetrazol. These data suggest that halogenation of CBN modifies the pharmacological profile of the cannabinoid.
- 社団法人日本薬学会の論文
- 1995-02-15
著者
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吉村 英敏
中村学園大学
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渡辺 和人
北陸大学薬学部
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渡辺 和人
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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山本 郁男
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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吉村 英敏
Department of Food and Nutrition, Nakamura Gakuen University
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宇佐見 則行
九州保健福祉大学薬学部衛生薬学講座 九州保健福祉大学qol研究機構
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Usami Noriyuki
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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宇佐見 則行
北陸大・薬
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吉田 久俊
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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宇佐見 則行
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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大石 泰正
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University
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大石 泰正
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Yoshimura H
Department Of Food And Nutrition Nakamura Gakuen University
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宇佐見 則行
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University
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吉村 英敏
Department Of Food And Nutrition Nakamura Gakuen University
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