Pharmacological Activities in the Mouse of Δ^9-Tetrahydrocannabinol Metabolites Oxidized at the 8-Position

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概要

• 論文の詳細を見る

• The pharmacological effects of Δ^9-tetrahydrocannabinol (THC) metabolites, 8α-hydroxy-Δ^9-THC (8α-OH-Δ^9-THC), 8β-OH-Δ^9-THC and 8-oxo-Δ^9-THC, were examined in the mouse. Cataleptogenic, hypothermic and pentobarbital-induced sleep-prolonging effects were produced by intravenous injection of the metabolites and compared with those of Δ^9-THC. In all the pharmacological indices, Δ^9-THC and 8-oxo-Δ^9-THC had the highest and the lowest activity, respectively. The activity of 8α-OH-Δ^9-THC was less potent in catalepsy and more potent in hypothermia than that of 8β-OH-Δ^9-THC, while they were equipotent in barbiturate synergism. These results suggest that oxidation at the 8-position is one of the detoxication pathways of Δ^9-THC, and also indicate the complexity of cannabinoid action in the central nervous system.

• 公益社団法人日本薬学会の論文
• 1985-01-25

著者

• 成松 鎮雄

  千葉大・薬

• 渡辺 和人

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 山本 郁男

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 吉村 英敏

  Department of Food and Nutrition, Nakamura Gakuen University

• 成松 鎮雄

  岡山大・薬・衛生化学

• 成松 鎭雄

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• 成松 鎮雄

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Hokuriku University

• 松原 一彦

  Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University

• 下西 龍之

  Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University

• Yoshida H

  Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.

• Narimatsu S

  Laboratory Of Biopharmaceutics Faculty Of Pharmaceutical Sciences Chiba University

• 松原 一彦

  Department Of Hygienic Chemistry School Of Pharmacy Hokuriku University

• 成松 鎮雄

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Hokuriku University

• 下西 龍之

  Department Of Hygienic Chemistry School Of Pharmacy Hokuriku University

• 吉村 英敏

  Department Of Food And Nutrition Nakamura Gakuen University

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